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(percentages for incidence of hepatotoxicity are based on listed product information and their relative patient studies) Some of the drugs that fall into these categories are listed below with a listed “incidence of hepatotoxicity” and/or product warnings. Alkylating Agents are chemicals that change the make-up of cancer cells.
Tyrosine Kinase Inhibitors are used to fight certain types of cancer. What chemotherapy drugs are likely to cause hepatotoxicity? A liver biopsy, x-rays or other imaging may be used to determine whether or not hepatotoxicity is present. Physicians may also perform other tests to determine if liver dysfunction is caused by chemotherapy drug treatments. Normal levels are in the range of 7-40 U/L. If liver damage is present elevated levels may be released. Asparatate aminotransferase aids in producing proteins.Normal levels are in the range of 5-50 U/L. Alanine aminotransferase aids in producing proteins.Normal levels are in the range of 100-220 U/L. Lactate dehydrogenase assists in energy production.Normal levels are in the range of 20-120 U/L. If liver dysfunction is present, it may be elevated due to the body’s inability to excrete it through bile. Alkaline phosphatase is an enzyme that is eliminated in bile.The following are enzymes that can be measured: Physicians can measure the enzymes, also known as proteins, of the liver to determine whether or not there may be damage in specific areas of the organ.
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Levels greater than 3.0 may cause a patient to have a jaundice or yellowish appearance to the skin and/or whites of the eyes.Įlevated liver enzymes: The measurement of liver enzymes in the blood can be used to indicate whether or not the liver is functioning normally. Normal bilirubin levels range between 0.2-1.2 mg/dL. If tests show increased levels are present, this may indicate liver damage from chemotherapy drug treatment. Bilirubin is normally present in the blood in small amounts. The following are blood tests used to determine if liver damage may be present:īilirubin blood levels: The liver uses a chemical called bilirubin to produce bile. The blood tests measure levels of substances that may be present in the blood and cause possible liver dysfunction. Stools that tend to be a lighter color than normalĪ primary way to diagnose whether or not liver damage may be present is through blood tests.Abnormal, rapid weight gain in a short period of time.Severe abdominal pain, nausea, or vomiting.A jaundice appearance (yellowish tone to the skin or whites of eyes).The following are hepatotoxicity-related symptoms: Patients may experience side effects that indicate hepatotoxicity during chemotherapy treatments. Liver dysfunction from chemotherapy drugs can lead to several symptoms. The result is an excess of chemotherapy drugs that overload the liver and cause hepatotoxicity. Liver damage can hinder the production of bile and lead to the body’s inability to flush out the chemicals through waste. The liver filters the chemotherapy substances out of the bloodstream and removes them through the bile. One of the functions of the liver is to produce a substance called bile that aids in the removal of these toxic drugs through body waste. How can chemotherapy cause hepatotoxicity?Ĭhemotherapy uses toxic chemicals or drugs to destroy cancer cells. When there is an excess of chemicals filtering through the liver, the overload is more than the liver can process and hepatotoxicity, or liver damage results. The liver functions as a filter that separates out harmful substances from the bloodstream. Hepatotoxicity refers to liver dysfunction as a result of an overload of toxic chemicals or drugs in the body. Hepatotoxicity from Chemotherapy Treatment You willīe contacted by a Mesothelioma Web co-ordinator who will be available
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